您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Neuropeptide W-23(human)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Neuropeptide W-23(human)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:383415-79-0
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
25 mg电议
100 mg电议

产品名称
NPW-23
产品介绍
Neuropeptide W-23(human) 是 NPBW1 和 NPBW2 的内源性配体,是 Neuropeptide W 的主要活性形式。

产品描述

Neuropeptide W-23(human) is an endogenous ligand for NPBW1 and NPBW2.

体外活性

NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7 which may involve in the development of vascular hypertension. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1].

体内活性

NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats[1]. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124 which suggests that orexin neurons are downstream targets of NPW [2].

Cas No.

383415-79-0

分子式

C120H184N34O28S

分子量

2583.02

别名

NPW-23;Neuropeptide W-23(human)

储存和溶解度

H2O:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years