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(RS)-AMPA monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:76463-67-7
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品介绍
(RS)-AMPA ((±)-AMPA) monohydrate 是谷氨酸的一种类似物,对兴奋性神经递质 L-谷氨酸 (L-glutamic acid) 有激动作用。(RS)-AMPA monohydrate 不会干扰海藻酸或 NMDA 受体的结合位点。

产品描述

(RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue that is a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors [1] [2].

体外活性

(RS)-AMPA monohydrate (10-3-10-4 M) leads to depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA monohydrate is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA monohydrate at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA monohydrate also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA monohydrate exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors [1].

Cas No.

76463-67-7

分子式

C7H12N2O5

分子量

204.18

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years