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Flumexadol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flumexadol图片
CAS NO:30914-89-7
包装:200 mg
市场价:8004元

产品介绍

产品描述

Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic.

体内活性

In rats and dogs dosed with 14C-Flumexadol (CERM1841), the 14C is excreted in the urine.?The 14C eliminated in the faeces of dog is significantly higher than for rat.?Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species.?Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances.?The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid.?In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate.?The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.

Cas No.

30914-89-7

分子式

C11H12F3NO

分子量

231.21

别名

Flumexadol

储存和溶解度

DMSO:100 mg/mL (432.51 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years