D-Leucine 具有抗癫痫特性，活性比L-leucine，能够有效终止癫痫发作。在体外，它能够抑制长期点位，但基底突触传递无影响。

D-Leucine potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.

D-Leucine failed to compete for binding by cognate ligands in a screen of candidate neuronal receptors, potentially suggesting a novel target. D-Leucine suppressed ongoing seizures at least as effectively as diazepam even at low doses, but without sedative effects. These studies raise the possibility that D-Leucine may represent a new class of anti-seizure agents, and that D-Leucine may have a previously unknown function in eukaryotes[1].

328-38-1

C6H13NO2

131.175

(R)-Leucine;D-亮氨酸;D-Leucine

DMSO:< 1 mg/mL,ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years