您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > NSI-189 Phosphate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NSI-189 Phosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NSI-189 Phosphate图片
CAS NO:1270138-41-4
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
NSI 189 Phosphate
NSI-189磷酸盐
NSI189 Phosphate
产品介绍
NSI-189 Phosphate 是一种新型神经源性分子,具有多效性,包括临床前研究中证明的抗抑郁、促认知、突触和神经营养活性。其抗抑郁活性不依赖于单胺。

产品描述

NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.

体内活性

NSI-189 actively stimulated remodeling of the stroke brain.?Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF.?These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hr time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke[1].

Cas No.

1270138-41-4

分子式

C22H33N4O5P

分子量

464.5

别名

NSI 189 Phosphate;NSI-189磷酸盐;NSI189 Phosphate;NSI-189 Phosphate

储存和溶解度

DMSO:65 mg/ml (139.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years