Glutamate-5-kinase-IN-1 (compound 50) 是一种有效的glutamate-5-kinase (G5K)抑制剂，MIC (最小抑制浓度)为 4.1 μM. Glutamate-5-kinase-IN-1 通过改变用于催化作用的 ATP 结合位点的构想改变显示 G5K 抑制作用。Glutamate-5-kinase-IN-1具有抗结核药物研究的潜力。

Glutamate-5-kinase-IN-1 (compound 50) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC (minimum inhibitory concentration) of 4.1 μM. Glutamate-5-kinase-IN-1 shows G5K inhibition by alters the ATP binding site architecture for enzyme recognition. Glutamate-5-kinase-IN-1 has the potential for the research of anti-TB agents [1].

Glutamate-5-kinase-IN-1 (compound 50) (40 μM) inhibits G5K activity with an I 0.5 of 22.1 μM at 10 mM concentration of L-Glu and ATP [1]. Glutamate-5-kinase-IN-1 (5, 10, 20 μM) shows no relevant cytotoxicity in HepG2 cells [1]. Glutamate-5-kinase-IN-1 (120 μM) causes a substantial increase in the Km app for ATP at constant concentrations of L-Glu (150 mM, 300 mM and 600 mM) and ATP (10 mM) [1].

C20H18N2O

302.37

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