MDL 72527 是一种多胺氧化酶 (POA) 抑制剂

MDL 72527 is a polyamine oxidase (POA) inhibitor

In the absence of CRP, exposure of platelets to MDL-72527 did not significantly modify [Ca2+]i, P-selectin abundance, αIIbβ3 integrin abundance, ROS, annexin-V-binding, and forward scatter. The addition of 2-5 μg/ml CRP was followed by significant increase of [Ca2+]i, P-selectin abundance, αIIbβ3 integrin activation, ROS abundance, annexin-V-binding, and aggregation as well as a significant decrease of forward scatter, all effects significantly blunted or virtually abolished in the presence of MDL-72527. MDL-72527 is a powerful inhibitor of platelet activation, apoptosis and aggregation[1].

93565-01-6

C12H22Cl2N2

265.22

N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride;MDL 72527

DMSO:20 mg/ml (75.41 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years