Citiolone 是硫醇衍生药物，可作为粘液溶解剂，用于治疗某些肝脏疾病。

Citiolone is a thiolic-derived medication as a mucolytic agent for the treatment of certain hepatic disorders.

OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. In addition, OSI-027 inhibits mTOR signaling of phospho-4E-BP1 with an IC50 of 1 μM in cell-based assays. [1] OSI-027 exhibits anti-proliferative activities against several acute leukemia cell lines of myeloid/megakaryocytic origin in a dose-dependent manner, including U937, KG-1, KBM-3B, ML-1, HL-60, and MEG-01 cells. [2] A recent study shows that inhibition of mTORC1/2 by OSI-027 effectively suppresses phosphorylation of Akt (S473) and cell proliferation in breast cancer cells. [3]

1195-16-0

C6H9NO2S

159.21

西替沃酮;Thioxidrene;Citiolase;Citiolone

Ethanol:29 mg/mL (182.1 mM)
DMSO:35 mg/mL (219.84mM)
H2O:29 mg/mL (182.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years