ICA 是有效的SK通道抑制剂。ICA显示出抗利什曼原虫的活性，IC50为2.1 μM。

ICA is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 μM).

ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters, at increased pacing frequencies. The SK channel inhibitor ICA shows antiarrhythmic effects. ICA at 1 to 10 μM displays conduction velocity[2].

3374-88-7

C13H10N4S

254.31

N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine;ICA

DMSO:49.5 mg/mL (194.64 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years