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Betaxolol hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Betaxolol hydrochloride图片
CAS NO:63659-19-8
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
盐酸倍他洛尔
SL 75212 HCl
SL75212
Betaxolol HCl
产品介绍
Betaxolol hydrochloride 是一种 β1 肾上腺素受体阻断剂,可用于研究高血压和青光眼。

产品描述

Betaxolol is a cardioselective beta-blocker used in the treatment of hypertension. Betaxolol has not been linked to instances of clinically apparent drug induced liver injury.

体外活性

Betaxolol 的内含物可以部分阻止NMDA 和缺氧/ 葡萄糖引起的改变.在大鼠局部贫血前和再灌注损伤的时候腹腔注射Betaxolol可以有效减少钙网膜蛋白和ChAT免疫反应性的改变,并且可以阻止b波下降.

体内活性

10 μM Betaxolol基本可以完全阻断谷氨酸酯诱导的LDH的释放。 100 μM Betaxolol能有效防止皮质组织中由缺氧引起的LDH的释放。Betaxolol能保护视网膜神经元。Betaxolol在β-肾上腺素受体激动剂无效时,会减弱NMDA诱导的45Ca2+流入。

细胞实验

Dissociated cortical cells from 16–18-day-old fetal rats are grown, in 35 mm dishes, in DMEM supplemented with L-glutamine (4 mM), glucose (6 g/L), penicillin (100 U/mL), streptomycin (100 μg/mL) and 10% hormonal supplemented medium consisting of transferrin (1 mg/mL), insulin (250 μg/mL) putrescine (600 μM), sodium selenite (0.3 μM), progesterone (0.2 μM) and estradiol (0.1 pM) for 7 days in an atmosphere of 5% CO2/95% O2 at 37 °C. The cultures are then transferred to a culture medium which lacks the hormonal supplemented medium. L-glutamate is added to the medium and incubated for a further 4 hours under normoxic conditions. Betaxolol are added to the cultures at the same time as L-glutamate. In other experiments the cultures are subjected to anoxic conditions, 95% N2/5% CO2, for 5 hours at 37 °C. Betaxolol is added prior to anoxia. Reoxygenation is then achieved by replacing the cells in normoxic conditions (95% O2/5% CO2) for 3 hours. Cellular injury is assessed by measuring lactate dehydrogenase (LDH) release into the cell culture supernatant after hypoxia/reoxygenation or glutamate exposure. LDH activity is assayed spectrophotometrically by following NADH metabolism for 2 minutes at 340 nm.(Only for Reference)

Cas No.

63659-19-8

分子式

C18H30ClNO3

分子量

343.89

别名

盐酸倍他洛尔;SL 75212 HCl;SL75212;Betaxolol HCl;Betaxolol hydrochloride

储存和溶解度

H2O:29.08mM
DMSO:200.6 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years