Piperoxan hydrochloride 是第一代抗组胺剂，是一种 α2肾上腺素受体拮抗剂。

Piperoxan hydrochloride is an α2 adrenoceptor antagonist. Piperoxan (benodaine) is a drug which was the very first antihistamine to be discovered.

When the medulla is superfused with Piperoxan (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxan applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations are superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxan (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxan (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxan potentiates a phrenic burst frequency increase: during the fifth minute of NA applications, the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition[1].

135-87-5

C14H20ClNO2

269.77

盐酸哌罗克生;Benodaine hydrochloride;dl-Piperoxan hydrochloride;Piperoxan hydrochloride

DMSO:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years