Dexpropranolol hydrochloride 是一种抗肾上腺素受体拮抗剂，是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-Adrenergic Receptor 拮抗剂，对 β1AR 和 β2AR 具有高亲和力。

Dexpropranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.

Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[4]. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[4].

13071-11-9

C16H22ClNO2

295.8

Dexpropranolol hydrochloride;盐酸普奈洛尔;(R)-(+)-Propranolol;(R)-Propranolol hydrochloride

DMSO:60 mg/ml (202.84 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years