Talipexole dihydrochloride 是一种多巴胺 D2 受体激动剂、α2-肾上腺素受体激动剂和 5-HT3 受体拮抗剂，有抗帕金森病活性。

Talipexole dihydrochloride is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.

Intracisternal injection of 10 μg/kg Talipexole dihydrochloride promotes vagal-mediated reflex bradycardia induced by injection of angiotensin in β-adrenoceptor-blocked dogs. Intravenous administration of Talipexole dihydrochloride at 30 mcg/kg initially caused an increase in blood pressure in cats. Then there is the long-term drop in blood pressure and heart rate[4].

36085-73-1

C10H16ClN3S

245.77

Domnin;B-HT 920 dihydrochloride;盐酸他利克索;Talipexole dihydrochloride

DMSO:22.5 mg/mL (79.72 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years