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OPC-28326
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OPC-28326图片
CAS NO:167626-17-7
包装:5 mg
市场价:7000元

产品介绍

产品描述

OPC-28326 is a selective peripheral vasodilator and an α2-adrenergic receptor angatonist(α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively).

体外活性

Using a human recombinant receptor and rat kidney cortex, we found that OPC-28326 displays affinities to alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptors with K(i) values of 2040, 285, and 55 nM, respectively. The K(i) values of yohimbine for alpha(2A)-, alpha(2B)-, and alpha(2C)-adrenoceptors were 3.0, 2.0 and 11.0 nM, respectively.

体内活性

OPC-28326 (3 - 30 mg kg(-1), i.v.) and yohimbine (0.3 - 3 mg kg(-1), i.v.) caused dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920. The apparent pA(2) values were 1.55 (0.87 - 2.75, 95% confidence interval) and 0.11 (0.06 - 0.21) mg kg(-1), respectively. The potency of OPC-28326 was about 14 times less than that of yohimbine.

Cas No.

167626-17-7

分子式

C26H35N3O2

分子量

421.58

别名

OPC-28326

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years