产品描述
Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.
体内活性
When given simultaneously i.v Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects.In a dose-dependent manner Vatinoxan attenuates or prevents dexmedetomidine's systemic hemodynamic effects. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently reduces bradycardia associated with dexmedetomidine and shortens the sedative effect without changing its quality. Vatinoxan may help reduce heart rate reduction in cats consciously administering dexmedetomidine[2].
Cas No.
130466-38-5
分子式
C20H27ClN4O4S
分子量
454.97
别名
MK-467 hydrochloride;L-659066 hydrochloride;Vatinoxan hydrochloride
储存和溶解度
H2O:133 mg/mL (292.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years