PSN 375963 hydrochloride 是一种有效的GPR119激动剂，对人和小鼠GPR119的EC50分别为 8.4 和 7.9 μM。PSN 375963 hydrochloride 表现出与内源性油酰乙醇酰胺 (OEA) 相似的效力。

PSN 375963 hydrochloride is a potent GPR119 agonist, with EC 50 s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride exhibits similar potency to the endogenous agonist oleoylethanolamide (OEA) [1] [2].

The endogenous ligand OEA signals via GPR119 in a manner similar to glucagon-like peptide-1 (GLP-1) and its receptor with respect to insulin secretion, intracellular calcium and cAMP [2].

1781834-82-9

C17H24ClN3O

321.84

PSN 375963 hydrochloride（388575-52-8 Free base）

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years