AAA-10 是一种具有口服活性的肠道细菌胆盐水解酶 (BSH) 抑制剂，对B. thetarBSH 和B. longumrBSH 的IC50值分别为 10 nM, 80 nM。

AAA-10 is an orally active gut bacterial bile salt hydrolases ( BSH ) inhibitor, with IC 50 s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively [1].

AAA-10 (100 μM; 24 h) inhibits BSH activity in bacterial cultures, with IC 50 s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively [1]. AAA-10 (20 μM; 2 h) significantly inhibits deconjugation of glycochenodeoxycholic acid- d 4 or taurocholic acid- d 4 substrates of human feces [1].

AAA-10 (30 mg/kg; orally gavage daily for 5 days) decreases the abundances of deoxycholic acid (DCA) and lithocholic acid (LCA) in mice feces starting in day 2-5 [1]. AAA-10 (30 mg/kg) displays high colonic exposure and low gut permeability [1]. Animal Model: 10-11 weeks old male C57Bl/6J mice [1] Dosage: 30 mg/kg Administration: Orally gavaged once daily for 5 days Result: Decreased the abundances of DCA and LCA in mice feces starting in day 2-5. Displayed high colonic exposure and low gut permeability.

C25H41FO5S

472.65

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years