Dexpramipexole dihydrochloride 是一种神经保护剂，是一种弱的非麦角类多巴胺受体激动剂。

Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and is a weak non-ergoline dopamine agonist.

Dextromethorphan has been found to have neuroprotective effects and is being studied for the treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptosis pathways, and improves cell survival in response to various neurotoxins and β-amyloid neurotoxicity. Compared with the S-(-) isomer, dextromethorphan has lower dopamine agonist activity.

104632-27-1

C10H19Cl2N3S

284.25

KNS-760704 dihydrochloride;R-(+)-Pramipexole dihydrochloride;(R)-Pramipexole dihydrochloride;普拉克索杂质D;右旋普拉克索二盐酸盐;Dexpramipexole dihydrochloride

DMSO:100 mg/mL (351.80 mM)
H2O:100 mg/mL (351.80 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years