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Loreclezole hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loreclezole hydrochloride图片
CAS NO:2227372-56-5
包装:5 mg
市场价:7000元

产品名称
R 72063 hydrochloride
产品介绍

产品描述

Loreclezole hydrochloride, an antiepileptic compound, is a selective GABA A receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.

体内活性

Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test[3]. Animal Model: Adult male Lister Hooded rats[3]. Dosage: 10, 25, 50 or 75 mg/kg. Administration: IP, 60 min before measurement of seizure threshold. Result: Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.

Cas No.

2227372-56-5

分子式

C10H7Cl4N3

分子量

310.99

别名

R 72063 hydrochloride;Loreclezole hydrochloride;Loreclezole hydrochloride

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years