产品描述
Loreclezole hydrochloride, an antiepileptic compound, is a selective GABA A receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
体内活性
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test[3]. Animal Model: Adult male Lister Hooded rats[3]. Dosage: 10, 25, 50 or 75 mg/kg. Administration: IP, 60 min before measurement of seizure threshold. Result: Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
Cas No.
2227372-56-5
分子式
C10H7Cl4N3
分子量
310.99
别名
R 72063 hydrochloride;Loreclezole hydrochloride;Loreclezole hydrochloride
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years