您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Aminooxyacetic acid hemihydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Aminooxyacetic acid hemihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aminooxyacetic acid hemihydrochloride图片
CAS NO:2921-14-4
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
氨氧基乙酸半盐酸盐
羧甲基羟胺半盐酸盐
Carboxymethoxylamine Hemihydrochloride
产品介绍
Aminooxyacetic acid hemihydrochloride 是一种苹果酸-天冬氨酸穿梭 (MAS) 抑制剂,也能抑制 GABA 降解酶GABA-T。

产品描述

Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.

体内活性

At various intervals after aminooxyacetic acid(AOAA) the rats were either injected with one of the convulsive drugs or sacrificed for analysis of the GABA concentration.?AOAA caused a rapid initial (0-30 min) and a later slower increase of GABA in cerebellum and whole brain.?In the synaptosomal fraction the GABA accumulation was delayed and less pronounced when compared to the whole brain.?The bicuculline induced convulsions were markedly potentiated during the first hour but completely blocked from 2-6 h after AOAA.?Picrotoxin showed a somewhat different pattern to bicuculline in the interactions with AOAA.?The initial strong potentiation was not observed but the later phase of protection was present.?In the interactions with 3-MPA, the effect of AOAA was always protective.?The time to onset of convulsions was gradually increased during the first 30 min after AOAA.?This protective effect remained practically unchanged up to 6 h after AOAA.?However, once started, the convulsions were generally of the same duration and intensity.?The results can be interpreted as GABA accumulating after AOAA stimulates GABA receptors to a degree more or less proportional to the whole brain GABA concentration and further that GABA synthetized in neurons is liberated, stimulates inhibitory bicuculline sensitive (predominant) and excitatory bicuculline insensitive receptors and is captured to a large extent by non-neuronal cells[1].

Cas No.

2921-14-4

分子式

C4H11ClN2O6

分子量

218.59

别名

氨氧基乙酸半盐酸盐;羧甲基羟胺半盐酸盐;Carboxymethoxylamine Hemihydrochloride;Aminooxyacetic acid hemihydrochloride

储存和溶解度

DMSO:42.9 mg/mL (392.50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years