您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Lesogaberan
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lesogaberan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lesogaberan图片
CAS NO:344413-67-8
包装与价格:
包装价格(元)
25 mg电议
50 mg电议

产品名称
AZD-3355
产品介绍

产品描述

Lesogaberan is an effective and selective GABAB receptor agonist (EC50: 8.6 nM for human recombinant GABAB receptors). For rat brain GABAB and GABAA receptors, the binding affinity (Kis) is 5.1 nM and 1.4 μM, respectively.

体外活性

Lesogaberan (3-30 nM) increases a human islet cell proliferation in vitro[2].

体内活性

Lesogaberan effectively stimulates recombinant human GABAB receptors and inhibits transient lower esophageal sphincter relaxation (TLESR) in dogs, with a biphasic dose-response curve[1]. Lesogaberan (7 μmol/kg) displays high oral availability (88% in the dog and 100% in the rat) and relatively low systemic clearance in female SpragueDawley rats[1]. Lesogaberan (0.08?mg/mL; 48 hours; p.o.) treatment, protects human islet β-cells from apoptosis in islet grafts in mice[2].

Cas No.

344413-67-8

分子式

C3H9FNO2P

分子量

141.08

别名

AZD-3355;Lesogaberan

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years