8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. It is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors (pKi: 8.23 and 8.95).

8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2].

Animal Model: Male Wistar rats (280-320 g) with Rotenone [2]. Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes

134865-70-6

C14H19NO2

233.31

AH-002;8-M-PDOT

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years