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KL201
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KL201图片
CAS NO:302939-48-6
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
KL201 是一种昼夜节律调制器,是CRY1选择性的 稳定剂, 对 CRY2 没有稳定作用。KL201 延长了细胞和组织中的昼夜节律周期。

产品描述

KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1].

体外活性

KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc while not affecting cellular viability[1]. KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3[1]. KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants[1].

Cas No.

302939-48-6

分子式

C17H14BrN3OS

分子量

388.28

别名

KL201

储存和溶解度

DMSO:250 mg/mL (643.87 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years