您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > NO-Indomethacin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NO-Indomethacin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NO-Indomethacin图片
CAS NO:301838-28-8
包装:50 mg
市场价:7587元

产品介绍

产品描述

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone. NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 μM, compared to >1,000 μM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.

Cas No.

301838-28-8

分子式

C28H30ClN3O9S

分子量

620.07

别名

NO-Indomethacin

储存和溶解度

Ethanol:0.5 mg/mL
DMF:PBS (pH 7.2)(1:1):0.5 mg/mL
DMF:30 mg/mL
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years