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Calcitonin(salmon)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Calcitonin(salmon)(trifluoroacetate salt)图片
CAS NO:171052-37-2
包装:1 mg
市场价:1314元

产品名称
Calcitonin (salmon) (trifluoroacetate salt)
产品介绍

产品描述

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM). Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg/mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg/kg). Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease.

Cas No.

171052-37-2

分子式

C147H241F3N44O50S2

分子量

3545.88

别名

Calcitonin (salmon) (trifluoroacetate salt)

储存和溶解度

H2O:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years