AAK1-IN-3 TFA 是一种喹啉类似物，一种可透过血脑屏障的适配蛋白 2 相关激酶 1 (AAK1) 抑制剂，IC50为 11 nM。AAK1-IN-3 具有用于神经病理性疼痛研究的潜力。

AAK1-IN-3 TFA, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC 50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research [1].

AAK1-IN-3 (compound (R)-31) TFA is brain-penetrant kinase inhibitors with a B/P ratio of 1.3 [1]. AAK1-IN-3 TFA inhibits AAK1 in HEK293 cells (IC50=108 nM) [1].

AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) TFA causes a 46% reduction of μ2 phosphorylation in C57BL6 mice [1].

C24H22F6N4O4

544.45

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years