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BMT-090605 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2231664-45-0
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议

产品介绍
BMT-090605 hydrochloride 是一种有效的选择性连接蛋白-2 相关激酶 1(AAK1)抑制剂,IC50值为 0.6 nM。BMT-090605 hydrochloride 显示抗伤害活性。BMT-090605 hydrochloride 抑制 BMP-2 诱导蛋白激酶 (BIKE) 和细胞周期蛋白 G 相关激酶 GAK,IC50值分别为 45 nM 和 60 nM。BMT-090605 hydrochloride 可用于神经性疼痛的研究。

产品描述

BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC 50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC 50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain [1].

体外活性

BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC 50 of 0.63 nM [1]. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC 50 values of 45 nM and 60 nM, respectively [1].

体内活性

BMT-090605 hydrochloride(intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord [1]. Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model) [1] Dosage: 0.3-3 μg/rat Administration: Intrathecal Result: Caused a dose-dependent reduction in thermal hyperalgesia.

Cas No.

2231664-45-0

分子式

C21H25ClN4O2

分子量

400.9

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years