Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix , clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascular ischemic events for patients without deficiencies in CYP2C19-related metabolism.

130209-90-4

C16H17Cl2NO2S

358.28

(±)-Clopidogrel (hydrochloride)

DMSO:20 mg/mL
Ethanol:5 mg/mL
DMF:20 mg/mL
DMSO:PBS(pH 7.2) (1:2):0.33 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years