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Vinpocetine(RGH-4405 AY-27,255)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vinpocetine(RGH-4405 AY-27,255)图片
CAS NO:42971-09-5
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)350.45
FormulaC22H26N2O2
CAS No.42971-09-5 (Vinpocetine);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 3 mg/mL (8.6 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info
Chemical Name: ethyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
InChi Key: DDNCQMVWWZOMLN-IRLDBZIGSA-N
InChi Code: InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
SMILES Code: O=C(C1=C[C@@](CCC2)(CC)[C@]3([H])N2CCC4=C3N1C5=C4C=CC=C5)OCC
SynonymsRGH-4405; TCV 3B, apovincaminic acid ethyl ester, ethyl apovincaminate, AY 27,255, RGH 4405, TCV-3B, AY-27,255, RGH4405, TCV3B, Cavinton, Intelectol
实验参考方法
In Vitro

In vitro activity: Vinpocetine has been reported to have a selective and noncompetitive inhibition of Ca2+ PDE and thus regulate cyclic GMP levels in smooth muscle. In addition, vinpocetine has been revealed to inhibit the activities of three resolvable PDE in the cytosol of rat aorta with Ki values of 14±2μM,>1000μM and>1000μM for Ca2+ PDE(+)CaM, cGMP PDE and cAMP PDE, respectively.


Cell Assay: Vinpocetine (Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.

In VivoVinpocetine has shown the potent inhibition of 5-HT-induced contractions in endothelium-intact rat aorta with an EC50 value of 1μM.
Animal modelRats
Formulation & DosageN/A
ReferencesBr J Pharmacol. 1989 Nov;98(3):725-34.