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Uridine 5'-diphosphate sodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Uridine 5'-diphosphate sodium salt图片
CAS NO:21931-53-3
包装:100 mg
市场价:-1元

产品介绍

产品描述

Uridine 5'-diphosphate sodium salt is a selective native agonist of the P2Y6 receptor (EC50: 300 nM; pEC50: 6.52), and also is a potent antagonist of P2Y14 (pEC50: 7.28).

体外活性

microglial CCL2 and CCL3 mRNA expression significantly induced by Uridine 5'-diphosphate sodium salt (100 μM; for 15 min)[2]. Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2]. Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2]. UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2]. Activation of NFATc1 and NFATc2 in microglia induced by Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) [2].

Cas No.

21931-53-3

分子式

C9H11N2Na3O12P2

分子量

470.106

别名

Uridine 5'-diphosphate sodium salt

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years