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MS 39
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MS 39图片
包装:5 mg
市场价:-1元

产品介绍
MS 39 is a potent, high affinity and selective Degrader (PROTAC?) of mutant epidermal growth factor receptor (EGFR), comprising gefitinib(Iressa) conjugated via a linker to a VHL ligand. MS 39 potently induces degradation of mutant EGFR (DC50 values are 5 nM and 3.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) lung cancer cell lines, respectively), but exhibits no significant effect in cell lines bearing wild-type EGFR at concentrations up to 10 μM. MS 39 inhibits proliferation of H3255 lung cancer cellsin vitro, and is bioavailable in mice following ip administration.

产品描述

MS 39 is a potent, high affinity and selective Degrader (PROTAC(R)) of mutant epidermal growth factor receptor (EGFR), comprising gefitinib(Iressa) conjugated via a linker to a VHL ligand. MS 39 potently induces degradation of mutant EGFR (DC50 values are 5 nM and 3.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) lung cancer cell lines, respectively), but exhibits no significant effect in cell lines bearing wild-type EGFR at concentrations up to 10 μM. MS 39 inhibits proliferation of H3255 lung cancer cellsin vitro, and is bioavailable in mice following ip administration.

别名

MS 39

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years