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VPC-18005
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VPC-18005图片
CAS NO:2242480-48-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
VPC-18005 是一种荧光素酶抑制剂。 VPC-18005 抑制 ERG 诱导的转录并直接与 ERG-ETS 结构域相互作用,从而破坏 ERG 与 DNA 的结合。

产品描述

VPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.

体外活性

VPC-18005 (1 and 10 μM) produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh[1]. VPC-18005 (5 μM) inhibits pETS-luc reporter activity with IC50s of 3 and 6 μM in PNT1B-ERG and VCaP cells, respectively. VPC-18005 antagonizes the metastatic potential of ERG-expressing prostate cells and suppresses ERG reporter activity without exhibiting overt cytotoxicity. VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro[2].

Cas No.

2242480-48-2

分子式

C15H17N3O3S

分子量

319.38

别名

VPC-18005

储存和溶解度

DMSO:60 mg/mL (187.86 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years