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Nuvenzepine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nuvenzepine图片
CAS NO:96487-37-5
包装:25 mg
市场价:10957元

产品介绍

产品描述

Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.

体外活性

Nuvenzepine is almost equipotent to pirenzepine in competitively preventing bethanechol-induced gall-bladder contractions and it shows a four-fold higher potency than pirenzepine in blocking vagal-stimulated tracheal constrictions. Nuvenzepine displays a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions on isolated ileal musculature and on longitudinal ileum dispersed cells [1].

体内活性

Nuvenzepine is also active, unlike pirenzepine, on colonic stimulated motility. In anaesthetized cats, intraduodenally administration of Nuvenzepine shows a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility. Nuvenzepine has been found to be very active in inhibiting gastric acid secretion and intestinal hypermotility in rats, with very slight atropine-like side effects. The oral absorption rate is relatively slow, that the absolute bioavailability is 30 to 40%, that the elimination rate is slow and there is no accumulation in the body, and that there is very little metabolism. Nuvenzepine displays a potency 10 times greater than that of pirenzepine on ileal motor activity. Nuvenzepine inhibits pentagastrin-stimulated gastric acid secretion resulting 25-30 times more potent than pirenzepine in conscious cats [2][3].

Cas No.

96487-37-5

分子式

C19H20N4O2

分子量

336.39

别名

Nuvenzepine

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years