产品描述
APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k i values of 0.1, 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.
体外活性
APC-6860 (compounds 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC 50 s of 1.4 and 3.1 μM, respectively[2].
Cas No.
154628-42-9
分子式
C9H7IN2S
分子量
302.13
别名
APC-6860
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years