产品描述
KDR-in-4 is an effective inhibitor of kinase insert domain-containing receptor (KDR/VEGFR2) (IC50: 7 nM).
体内活性
At doses of 100 mg/kg, KDR-in-4 (p.o.) results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model. 30 mg/kg doses of KDR-in-4 shows a 70% and 80% reduction in lesion size in the laser CNV and rat oxygen-induced retinopathy (OIR) models, respectively [2].
Cas No.
408502-06-7
分子式
C23H25N3O3
分子量
391.46
别名
KDR-in-4;VEGFR-2-IN-9
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years