Pentiapine 是一种新型的多巴胺释放抑制剂。

Pentiapine is a novel inhibitor of dopamine release.

Pentiapine dose-dependently reduces motor activity of mice. Pentiapine dose-dependently reduces morphine-induced hyperactivity. Newman-Keuls post-hoc comparisons indicate that the group receiving morphine plus saline presents more activity than the groups receiving morphine plus 2 (P<0.05), 4, 8, 16, 24 and 32 (P<0.01) mg/kg of Pentiapine. Moreover, the groups receiving morphine plus 0.5, 1 and 2 mg/kg of Pentiapine present more activity than the groups receiving morphine plus 4, 8, 16, 24 and 32 mg/kg of Pentiapine (P<0.01)[1]. 30 mg/kg dose of Pentiapine completely blocks the methylenedioxymethamphetamine (MDMA) conditioned place preference (CPP) and also blocks the establishment of a cocaine CPP[2].

81382-51-6

C15H17N5S

299.39

CGS 10746;喷硫平;Pentiapine

DMSO:95 mg/mL (317.31 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years