K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).

K-252a is an effective inhibitor (IC50: 3 nM) of the tyrosine-protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk proto-oncogene [3].

99533-80-9

C27H21N3O5

467.47

Antibiotic SF 2370;Antibiotic K 252a;SF2370;K-252a

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years