(E)-SI-2 是类固醇受体 coactivator-3（Src-3 或 AIB1）的有效小分子抑制剂，可选择性抑制 Src-3 的内在转录活性，也抑制 Src-1 和 Src-2。它选择性地降低 Src-3 的细胞蛋白水平，但不降低 CARM-1 的细胞蛋白水平，阻断 MDA-MB-468 细胞生长，IC50 值为 3.4 nM，但不影响正常细胞。

(E)-SI-2 is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2. It selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells.

380537-35-9

(E)-SI-2

DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years