AZ506 是有效的SMYD2抑制剂，IC50为 17 nM。AZ506 抑制细胞中 SMYD2 甲基转移酶的活性，导致 SMYD2 介导的甲基化信号减少。

AZ506 is a potent SMYD2 inhibitor with an IC 50 of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal [1].

AZ506 inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with an EC 50 of 1.2 μM. AZ506 inhibits SMYD2-mediated methylation (p53-me in U2OS cells) with an IC 50 of 2.43 μM [1].

2043321-54-4

C33H40N6O

536.71

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years