PFI-2 是一种有效、特异性和细胞活性的赖氨酸甲基转移酶 SETD7 抑制剂，Ki和IC50值分别为 0.33 和 2 nM。

PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

在细胞环境中,通过与SETD7的直接作用,PFI-2可影响Hippo通路信号中Yes相关蛋白定位和拟表型Setd7基因缺失。(R)-PFI-2对人SETD7的抑制活性比其异构体,(S)-PFI-2高500倍。

1627676-59-8

C23H25F4N3O3S

499.52

PFI2;PFI 2;(R)-PFI-2;PFI-2

Ethanol:66 mg/mL (132.12 mM),warmed
DMSO:>10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years