Pociredir (FTX-6058) 是一种有效的、选择性的口服胚胎外胚层发育蛋白 (EED) 小分子抑制剂，其KD值为 0.163 nM。Pociredir (FTX-6058) 可用于研究炎症或血红蛋白病，如镰状细胞病 (SCD)。

Pociredir (FTX-6058) is a potent, selective and orally active small-molecule inhibitor of embryonic ectoderm development (EED) with K D value of 0.163 nM. Pociredir (FTX-6058) can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease (SCD) [1] [2].

Pociredir (FTX-6058) (QD, 5 mg/kg) reduces the H3K27me3 levels in the Townes mouse model of sickle cell disease (SCD). Pociredir (FTX-6058) (QD, 5 mg/kg) increases the levels of red blood cells and total hemoglobin, ameliorates hemolysis in the Townes mouse model of sickle cell disease (SCD) [1].

2490674-02-5

C22H18FN5O2

403.41

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years