NAMPT-IN-10 TFA (compound 4) 是磷酸核糖转移酶(NAMPT)的抑制剂。NAMPT-IN-10 TFA 对 A2780 和 CORL23 具有细胞效能，IC50值分别为 5 和 19 nM。NAMPT-IN-10 TFA 可以作为 ADCs 的非抗有丝分裂有效载荷。

Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC 50 s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs [1].

Nampt-IN-10 TFA (0-1 μM; 72 h) shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines [1]. Cell Cytotoxicity Assay [1] Cell Line: A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines Concentration: 0-1 μM Incubation Time: 72 hours Result: Showed cellular potency towards A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC 50 values of 5, 19, 2, 0.4 and 1 nM, respectively.

2567724-20-1

C29H29F4N5O4

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years