C-Phycocyanin 是一种蛋白质色素，常作为人类的优良营养补充剂。

C-Phycocyanin is a water-soluble protein pigment that is also used as a nutrient supplement for human beings.

For the combination experiments, when cells treated with All-trans retinoic acid (ATRA) combined with C-phycocyanin, the IC50 value is lower than that in the ATRA group. But under the same IC50, the more C-phycocyanin is used, the less ATRA is needed. C-phycocyanin combined with ATRA can significantly decrease the CDK-4 mRNA level (P<0.05). The combination index (CI) value of the C-phycocyanin+ATRA combination group is 0.852 which is less than 1, indicating that the two drugs are synergetic under the action concentration (88 μg/L C-phycocyanin+0.102 mM ATRA). The expression of caspase-3 in the C-phycocyanin group is more than that in the control group but is similar to that in the ATRA group, whereas the expression in the combination group is maximum.

Compare with the control group, the average tumor weights of mice in solely C-phycocyanin or ATRA treatment groups are significantly decreased, and further reduced in the C-phycocyanin+ATRA synergy group. Single C-phycocyanin can increase the spleen weight of mice but the effects of ATRA are just the opposite. C-phycocyanin can also promote the growth of immune organs in mice and increase the body's immune function. C-phycocyanin and ATRA alone can significantly inhibit Cyclin D1 expression, and when being combined, the inhibitory effect is more obvious.

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藻蓝蛋白;C-藻蓝蛋白;C-PC;C-Phycocyanin

H2O:14.29 mg/mL,Need ultrasonic
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