The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase mediates the rate-limiting step in cholesterol synthesis, converting HMG-CoA to mevalonate. 3-hydroxy-3-Methylglutaric anhydride is a precursor that is used in the synthesis of HMG-CoA. It has also been used in the synthesis of 3-alkyl-3-hydroxyglutaric acids that act as inhibitors of HMG-CoA reductase.

34695-32-4

C6H8O4

144.13

3-hydroxy-3-Methylglutaric anhydride

DMSO:10 mg/mL
Ethanol:10 mg/mL
DMF:10 mg/mL
PBS (pH 7.2):10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years