Gut restricted-7 是一种具有口服活性的共价泛胆盐水解酶 (BSH) 抑制剂，对肠道有组织选择性。它可减少小鼠粪便中肠道细菌的BSH活性并降低去结合型胆汁酸水平。

Gut restricted-7 (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.

Gut restricted-7 (60 μM) does not affect the epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic.?Gut restricted-7 also does not affect microbial biomass.

The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (w/w) for 1 d day or powdered chow alone.?Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitor-treated mice 8 h post-diet change.?20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected.

2553218-46-3

C25H40FNaO6S

510.63

GR-7;Gut restricted-7

DMSO:250 mg/mL (489.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years