Rupintrivirvr is an effective and irreversible inhibitor of human rhinovirus 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays (EC50: 0.023 μM). Rupintrivirvr displays the immune-modulatory effect.

In H1-HeLa and MRC-5 cell protection assays, Rupintrivirvr inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50: 0.023 μM (range, 0.003 to 0.081 μM) and a mean EC90: 0.082 μM (range, 0.018 to 0.261 μM)) [1].

Rupintrivirvr decreases RV-induced TH-2 cytokine IL-4 in precision-cut lung slices of HDM-sensitized mice [2].

223537-30-2

C31H39FN4O7

598.66

AG7088;Rupintrivir

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years