MtTMPK-IN-2 (compound 15) 是一种有效的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂，IC50为 1.1 μM。MtTMPK-IN-2 对MtbH37Rv 具有抑制活性 (MIC = 12.5 μM)。MtTMPK-IN-2 对人成纤维细胞 MRC-5 具有一定的细胞毒性 (EC50= 6.1 μM)。MtTMPK-IN-2 可用于结核病的研究。

MtTMPK-IN-2 (compound 15) is a potent Mycobacterium tuberculosis thymidylate kinase ( Mt TMPK) inhibitor with an IC 50 value of 1.1 μM. MtTMPK-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-2 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC 50 = 6.1 μM). MtTMPK-IN-2 can be used for researching tuberculosis [1].

C23H24ClN3O3

425.91

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years