MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester prodrug of MPC-3100 with improved chemical stability.

MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the T max , C max , AUC and F% are 1?(h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively[1].MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals[1].MPC-0767 is well tolerated when administered at 252?mg/kg po (equivalent to 200?mg/kg dose of?MPC-3100)[1].

1310540-32-9

C26H36BrN7O9S2

734.64

MPC-0767

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years