SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).

2379550-82-8

C11H6F3N5O3

313.19

SHS4121705

Ethanol:30 mg/mL
DMSO:25 mg/mL
DMF:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years