UNC7467 是一种有效的IP6K抑制剂，IP6K2、IP6K1 和 IP6K6 的IC50值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平，而不会显着干扰其他肌醇磷酸盐的水平。UNC7467 可用于肥胖研究。

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates without significantly perturbing levels of other inositol phosphates. UNC7467 can be used for obesity research [1].

UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces inositol pyrophosphates levels. UNC7467 reduces 5-InsP 7 levels by 81% and 5-InsP 8 levels by 63% [1].

UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) improved diet-induced obesity, insulin resistance, and hepatic steatosis [1]. UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUC last (6054 h ng/mL for intra venous (i.v.) and 2527 h ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose [1]. Animal Model: Diet-induced obesity (DIO) mice [1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily, for 4 weeks Result: Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake. Animal Model: Diet-induced obesity (DIO) mice [1] Dosage: 5 mg/kg (Pharmacokinetic Analysis) Administration: Intravenous injection and intraperitoneal injection Result: 1.19 route iv ip Dose (mg/kg) 5 5 AUC last (h*ng/mL) 6054 2527 CL (mL/min/kg) 13.7

T60164

C20H13NO3

315.32

UNC7467

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years